Immunodynamics: a cancer immunotherapy trials network review of immune monitoring in immuno-oncology clinical trials

Holbrook E. Kohrt1, Paul C. Tumeh2, Don Benson3, Nina Bhardwaj4, Joshua Brody5, Silvia Formenti6, Bernard A. Fox7, Jerome Galon8, Carl H. June9, Michael Kalos10, Ilan Kirsch11, Thomas Kleen12, Guido Kroemer13, Lewis Lanier14, Ron Levy15, H. Kim Lyerly16, Holden Maecker17, Aurelien Marabelle18, Jos Melenhorst19, Jeffrey Miller20, Ignacio Melero21, Kunle Odunsi22, Karolina Palucka23, George Peoples24, Antoni Ribas25, Harlan Robins26, William Robinson27, Tito Serafini28, Paul Sondel29, Eric Vivier30, Jeff Weber31, Jedd Wolchok32, Laurence Zitvogel33, Mary L. Disis34, Martin A. Cheever35 and on behalf of the Cancer Immunotherapy Trials Network (CITN) 1Division of Oncology, Stanford Cancer Institute, Stanford University Medical Center, Stanford, CA, USA.2Division of Dermatology, Department of Medicine, University of California Los Angeles, Los Angeles, CA USA.3Division of Hematology/Oncology, Ohio State University, Columbus, OH USA.4Medicine, Hematology and Medical Oncology, Mount Sinai Hospital, New York, NY USA.5Medicine, Hematology and Medical Oncology, Mount Sinai Hospital, Ruttenberg Treatment Center, New York, NY USA. 6Department of Radiation Oncology, New York Weill Cornell Medical Center, New York, NY USA.7SOM-Molecular Microbiology & Immunology Department, Laboratory of Molecular and Tumor Immunology, OHSU Cancer Institute, Portland, OR USA. 8INSERM, Integrative Cancer Immunology Team, Cordeliers Research Center, Paris, France. 9Perelman School of Medicine, University of Pennsylvania, Pathology and Laboratory Medicine, Philadelphia, PA USA.10Cancer Immunobiology, Eli Lilly & Company, New York, NY USA. 11Translational Medicine, Adaptive Biotechnologies Corp, Seattle, WA USA. 12Immune Monitoring, Epiontis GmbH, Berlin, Germany. 13Faculty of Medicine, University of Paris Descartes, Paris, France. 14Department of Microbiology and Immunology, University of California, San Francisco, CA USA. 15Division of Oncology, Stanford School of Medicine, Stanford, CA USA. 16Duke University School of Medicine, Durham, NC USA. 17Human Immune Monitoring Center Shared Resource, Stanford Cancer Institute, Stanford, CA USA.18Léon Bérard Cancer Center, Lyon, France. 19Product Development and Correlative Sciences, Smilow Center for Translational Research, Philadelphia, PA USA. 20Division of Hematology, Experimental Therapeutics, University of Minnesota, Oncology and Transplantation, Minneapolis, MN USA. 21Centro de Investigacion Medica Aplicada, Universidad de Navarra, Avda. Pamplona, Spain. 22Center for Immunotherapy, Roswell Park Cancer Institute, Buffalo, NY USA. 23Baylor Institute for Immunology Research, Dallas, TX USA. 24Cancer Vaccine Development Program, Brooke Army Medical Center, Houston, TX USA. 25Tumor Immunology Program Area, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA USA. 26Adaptive Biotechnologies, Seattle, WA USA. 27Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA USA. 28Atreca, Inc, Redwood City, CA USA. 29Cellular & Molecular Pathology Graduate Program, University of Wisconsin-Madison, Madison, WI USA. 30Centre d'Immunologie de Marseille-Luminy, Marseille, France. 31Moffitt Cancer Center, Tampa, FL USA. 32Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, NY USA. 33Institut National de la Santé et Recherche Médicale, Institut GrustaveRoussy, Villejuif, France. 34Tumor Vaccine Group, University of Washington, Seattle, WA USA.35Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1023 USA.