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Immunogenic neoantigens derived from gene fusions stimulate T cell responses

Yang et al.
Nature Medicine
April 2019
Authors and Affiliates
Yang W1,2, Lee KW1, Srivastava RM2, Kuo F2, Krishna C3, Chowell D2, Makarov V2, Hoen D2, Dalin MG4, Wexler L5, Ghossein R6, Katabi N6, Nadeem Z7, Cohen MA7, Tian SK8, Robine N8, Arora K8, Geiger H8, Agius P8, Bouvier N9, Huberman K9, Vanness K9, Havel JJ1,2, Sims JS2, Samstein RM10, Mandal R2,7, Tepe J7, Ganly I7, Ho AL11, Riaz N2,10, Wong RJ7, Shukla N6, Chan TA12,13,14, Morris LGT15,16,17; 1 Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 2 Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 3 Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 4 Department of Pediatrics, Institute of Clinical Sciences, University of Gothenburg, Gothenburg, Sweden. 5 Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 6 Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 7 Department of Surgery (Head and Neck Service), Memorial Sloan Kettering Cancer Center, New York, NY, USA. 8 New York Genome Center, New York, NY, USA. 9 Integrated Genomics Operation, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 10 Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 11 Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 12 Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. chant@mskcc.org. 13 Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, NY, USA. chant@mskcc.org. 14 Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. chant@mskcc.org. 15 Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. morrisl@mskcc.org. 16 Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, NY, USA. morrisl@mskcc.org. 17 Department of Surgery (Head and Neck Service), Memorial Sloan Kettering Cancer Center, New York, NY, USA. morrisl@mskcc.org.