Immunoglobulin somatic hypermutation has clinical impact in DLBCL and potential implications for immune checkpoint blockade and neoantigen-based immunotherapies

Xu-Monette ZY1,2, Li J2, Xia Y2, Crossley B3, Bremel RD4, Miao Y2, Xiao M2, Snyder T3, Manyam GC5, Tan X2, Zhang H2, Visco C6, Tzankov A7, Dybkaer K8, Bhagat G9, Tam W10, You H11, Hsi ED12, van Krieken JH13, Huh J14, Ponzoni M15, Ferreri AJM15, Møller MB16, Piris MA17, Winter JN18, Medeiros JT2, Xu B19, Li Y20, Kirsch I3, Young KH21,22,23; 1 Hematopathology Division, Department of Pathology, Duke University School of Medicine, Durham, NC, 27710, USA. 2 Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. 3 Adaptive Biotechnologies, Seattle, WA, USA. 4 ioGenetics LLC, Madison, WI, USA. 5 Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. 6 San Bortolo Hospital, Vicenza, Italy. 7 Institute of Pathology and Medical Genetics, University Hospital of Basel, Basel, Switzerland. 8 Aalborg University Hospital, Aalborg, Denmark. 9 Columbia University Medical Center and New York Presbyterian Hospital, New York, NY, USA. 10 Weill Medical College of Cornell University, New York, NY, USA. 11 Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, China. 12 Cleveland Clinic, Cleveland, OH, USA. 13 Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands. 14 Asan Medical Center, Ulsan University College of Medicine, Seoul, Korea. 15 San Raffaele H. Scientific Institute, Milan, Italy. 16 Odense University Hospital, Odense, Denmark. 17 Hospital Universitario Marqués de Valdecilla, Santander, Spain. 18 Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. 19 Department of Hematology, The First Affiliated Hospital of Xiamen University, Xiamen, China. 20 Department of Medicine, Baylor College of Medicine, Houston, TX, USA. 21 Hematopathology Division, Department of Pathology, Duke University School of Medicine, Durham, NC, 27710, USA. ken.young@duke.edu. 22 Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. ken.young@duke.edu. 23 Duke University Medical Center, Duke Cancer Institute, Durham, NC, 27710, USA. ken.young@duke.edu.