Immunotyping of clinically divergent p.Phe508del homozygous monozygous cystic fibrosis twins

Esther Schamschula 1, Wolfgang Hagmann 2, Yassen Assenov 2, Silke Hedtfeld 3, Ahmed K Farag 4, Lennart M Roesner 4, Lutz Wiehlmann 5, Frauke Stanke 6, Sebastian Fischer 3, Angela Risch 7, Burkhard Tümmler 8; 1Department of Biosciences, Paris Lodron University of Salzburg, Salzburg, Austria. 2Division of Epigenomics, DKFZ - German Cancer Research Center, Heidelberg, Germany. 3Clinic for Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany. 4Department of Dermatology and Allergy, Division of Immunodermatology and Allergy Research, Hannover Medical School, Hannover, Germany. 5Clinic for Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany; Research Core Unit Genomics, Hannover Medical School, Hannover, Germany. 6Clinic for Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research, Hannover Medical School, Hannover, Germany. 7Department of Biosciences, Paris Lodron University of Salzburg, Salzburg, Austria; Division of Epigenomics, DKFZ - German Cancer Research Center, Heidelberg, Germany; Translational Lung Research Center Heidelberg (TLRC-H), German Center for Lung Research (DZL), Heidelberg, Germany. 8Clinic for Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research, Hannover Medical School, Hannover, Germany. Electronic address: tuemmler.burkhard@mh-hannover.de.