Interferon gene therapy reprograms the leukemia microenvironment inducing protective immunity to multiple tumor antigens

Giulia Escobar1,2,3, Luigi Barbarossa2,3, Giulia Barbiera3, Margherita Norelli1,4, Marco Genua3, Anna Ranghetti2, Tiziana Plati3, Barbara Camisa4, Chiara Brombin5, Davide Cittaro 3,6, Andrea Annoni3, Attilio Bondanza1,4, Renato Ostuni3, Bernhard Gentner3,7 & Luigi Naldini1,2,3 1Vita-Salute San Raffaele University, 20132 Milan, Italy. 2Targeted Cancer Gene Therapy Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy. 3San Raffaele Telethon Institute for Gene Therapy, 20132 Milan, Italy. 4Division of Immunology, Transplant and Infectious Diseases, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy. 5CUSSB-University Center for Statistics in the Biomedical Sciences, Vita-Salute San Raffaele University, 20132 Milan, Italy. 6Centre for Translational Genomics and Bioinformatics, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy. 7Hematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.