Intramuscular Therapeutic Vaccination Targeting HPV16 Induces T Cell Responses That Localize in Mucosal Lesions

Maldonado L1*, Teague JE2*, Morrow MP3*, Jotova I4, Wu TC5, Wang C6, Desmarais C7, Boyer JD8, Tycko B4, Robins HS9, Clark RA2, Trimble CL1,5,10 1 Department of Gynecology and Obstetrics, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA. 2 Harvard Skin Disease Research Center and the Department of Dermatology, Brigham and Women's Hospital, Boston, MA 02115, USA. 3 Inovio Pharmaceuticals Inc., 1787 Sentry Parkway West, Building 18, Suite 400, Blue Bell, PA 19422, USA. 4 Department of Pathology and Cell Biology and Institute for Cancer Genetics, Columbia University Medical Center, New York, NY 10025, USA. 5 Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA. 6 Oncology Biostatistics, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA. 7 Adaptive Biotechnologies, 1551 Eastlake Avenue, Seattle, WA 98102, USA. 8 Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. 9 Program in Computational Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. 10 Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA. * Contributed equally