Molecular Profiling Reveals Unique Immune and Metabolic Features of Melanoma Brain Metastases

Fischer GM1,2,3, Jalali A4, Kircher DA5, Lee WC6, McQuade JL2, Haydu LE7, Joon AY8, Reuben A9, de Macedo MP10, Carapeto FCL3, Yang C11, Srivastava A12, Ambati CR13,14, Sreekumar A13,14, Hudgens CW3, Knighton B2, Deng W2, Ferguson SD15, Tawbi HA2, Glitza IC2, Gershenwald JE1,7, Vashisht Gopal YN2,3, Hwu P2, Huse JT3,16, Wargo JA6,7, Futreal PA6, Putluri N13,14, Lazar AJ3,6,16, DeBerardinis RJ11,17, Marszalek JR18, Zhang J6, Holmen SL5,19, Tetzlaff MT3,16, Davies MA20,3,21 1 Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas. 2 Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. 3 Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas. 4 Department of Neurosurgery, Baylor College of Medicine, Houston, Texas. 5 Department of Oncological Sciences, University of Utah Health Sciences Center, Salt Lake City, Utah. 6 Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas. 7 Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. 8 Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas. 9 Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. 10 Department of Pathology, A.C. Camargo Cancer Center, São Paulo, Brazil. 11 Children's Medical Research Institute, The University of Texas Southwestern Medical Center, Dallas, Texas. 12 Department of Computational Sciences, The Jackson Lab for Genomic Medicine, Farmington, Connecticut. 13 Department of Molecular and Cell Biology, Baylor College of Medicine, Houston, Texas. 14 Advanced Technology Core, Alkek Center for Molecular Discovery, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas. 15 Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas. 16 Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas. 17 Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, Texas. 18 Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, Texas. 19 Department of Surgery, University of Utah Health Sciences Center, Salt Lake City, Utah. 20 Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. mdavies@mdanderson.org. 21 Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.