Next Generation Sequencing Reveals Restriction and Clonotypic Expansion of Regulatory T Cells in Juvenile Idiopathic Arthritis

Lauren A. Henderson, MD, MMSc1 ; Stefano Volpi, MD1 ; Francesco Frugoni, MS1 ; Erin Janssen, MD, PhD1 ; Susan Kim, MD, MMSc1 ; Robert P. Sundel, MD1 ; Fatma Dedeoglu, MD1 ; Mindy S. Lo, MD, PhD1 ; Melissa M. Hazen, MD1 ; Mary Beth Son, MD1 ; Ronald Mathieu, MStox, MPHD2 ; David Zurakowski, PhD3 ; Neng Yu, MD4 ; Tatiana Lebedeva, PhD4 ; Robert C. Fuhlbrigge, MD, PhD1,5; Jolan E. Walter, MD, PhD1,6; Yu Nee Lee, PhD1 ; Peter A. Nigrovic, MD1,7; Luigi D. Notarangelo, MD1,8 1Division of Immunology, Boston Children’s Hospital, Boston, MA 2Division of Hematology and Oncology, Boston Children’s Hospital, Boston, MA 3Department of Anesthesia, Boston Children’s Hospital, Boston, MA 4American Red Cross Blood Services-East Division, New England HLA Services, Dedham, MA 5Department of Dermatology, Brigham and Women’s Hospital, Boston, MA 6Division of Pediatric Allergy/Immunology, Massachusetts General Hospital for Children, Boston, MA, USA 7Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Boston, MA 8Harvard Stem Cell Institute, Boston, MA