Oncolytic Viruses Engineered to Enforce Leptin Expression Reprogram Tumor-Infiltrating T Cell Metabolism and Promote Tumor Clearance

Dayana B. Rivadeneira,1,2 Kristin DePeaux,1,2 Yiyang Wang,1,2,5 Aditi Kulkarni,4 Tracy Tabib,3 Ashley V. Menk,1,2 Padmavathi Sampath,2 Robert Lafyatis,3 Robert L. Ferris,1,2,4 Saumendra N. Sarkar,2 Stephen H. Thorne,2 and Greg M. Delgoffe1,2,4,6,*; 1Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA 2Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA 3Division of Rheumatology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA 4Head and Neck Cancer SPORE, University of Pittsburgh, Pittsburgh, PA, USA 5School of Medicine, Tsinghua University, Beijing, China 6Lead Contact