Origin of Enriched Regulatory T Cells in Patients Receiving Combined Kidney/Bone Marrow Transplantation to Induce Transplantation Tolerance

Ben Sprangers1, Susan DeWolf1, Thomas M. Savage1, Tatsuaki Morokata2, Aleksandar Obradovic1, Samuel A. LoCascio1, Brittany Shonts1, Julien Zuber1, Sai ping Lau1, Ravi Shah1, Heather Morris1, Valeria Steshenko6, Emmanuel Zorn1, Frederic I. Preffer3, Sven Olek7, David M. Dombkowski3, Laurence A. Turka2,5, Robert Colvin3, Robert Winchester6, Tatsuo Kawai4, and Megan Sykes1,2 1Columbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, New York, NY, USA, 2Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital (MGH)/Harvard Medical School (HMS), Boston, MA, USA, 3Department of Pathology, MGH/ HMS, Boston, MA, USA, 4Transplantation Unit, Department of Surgery, MGH/HMS, Boston, MA, USA, 5Immune Tolerance Network, Seattle, WA, USA, 6Division of Rheumatology, Department of Medicine, Columbia University Medical Center, New York, NY, USA