Spatially resolved analyses link genomic and immune diversity and reveal unfavorable neutrophil activation in melanoma

Akash Mitra, Miles C. Andrews, Whijae Roh, Marianna Petaccia De Macedo, Courtney W. Hudgens, Fernando Carapeto, Shailbala Singh, Alexandre Reuben, Feng Wang, Xizeng Mao, Xingzhi Song, Khalida Wani, Samantha Tippen, Kwok-Shing Ng, Aislyn Schalck, Donald A. Sakellariou-Thompson, Eveline Chen, Sangeetha M. Reddy, Christine N. Spencer, Diana Wiesnoski, Latasha D. Little, Curtis Gumbs, Zachary A. Cooper, Elizabeth M. Burton, Patrick Hwu, Michael A. Davies, Jianhua Zhang, Chantale Bernatchez, Nicholas Navin, Padmanee Sharma, James P. Allison, Jennifer A. Wargo, Cassian Yee, Michael T. Tetzlaff, Wen-Jen Hwu, Alexander J. Lazar & P. Andrew Futreal; 1Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. 2Quantitative Sciences Graduate Training Program, Graduate School of Biomedical Sciences, Houston, Texas, USA. 3Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. 4Olivia Newton-John Cancer Research Institute and School of Cancer Medicine, La Trobe University, Heidelberg, VIC, Australia. 5The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. 6Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. 7Department of Immunology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. 8Department of Thoracic Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. 9Institute for Personalized Cancer Therapy, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. 10Department of Genetics, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. 11Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. 12Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. 13Parker Institute for Cancer Immunotherapy, San Francisco, California, USA. 14AstraZeneca, Gaithersburg, Maryland, USA. 15Department of Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. 16Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. AFutreal@mdanderson.org.