Successive annual influenza vaccination induces a recurrent oligoclonotypic memory response in circulating T follicular helper cells

Ramin Sedaghat Herati,1,2 Alexander Muselman,1,2 Laura Vella,2,3 Bertram Bengsch,2,4 Kaela Parkhouse,5 Daniel Del Alcazar,1,2 Jonathan Kotzin,2,4 Susan A. Doyle,6 Pablo Tebas,1 Scott E. Hensley,2,4,5 Laura F. Su,1,2 Kenneth E. Schmader,6 E. John Wherry2,4 1Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. 2Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. 3Department of Medicine, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA. 4Department of Mi- crobiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. 5Wistar Institute, Philadelphia, PA 19104, USA. 6Division of Geriatrics, De- partment of Medicine, Duke University Medical Center and Geriatric Research, Educa- tion, and Clinical Center, Durham VA Medical Center, Durham, NC 27705, USA.