The Immune Phenotype of Isolated Lymphoid Structures in Non-Tumorous Colon Mucosa Encrypts the Information on Pathobiology of Metastatic Colorectal Cancer

Felicitas Mungenast 1,†, Anastasia Meshcheryakova 1,†,*, Andrea Beer 2, Martina Salzmann 1, Dietmar Tamandl 3, Thomas Gruenberger 4,‡, Peter Pietschmann 1, Oskar Koperek 2,§, Peter Birner 2, Ilan Kirsch 5, Harlan Robins 5, Martina Mittlboeck 6, Markus Jaritz 7, Michael Bergmann 8, Philip Zimmermann 9 and Diana Mechtcheriakova 1,*; 1 Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna 1090, Austria; felicitas.mungenast@meduniwien.ac.at (F.M.); martina.salzmann@meduniwien.ac.at (M.S.); peter.pietschmann@meduniwien.ac.at (P.P.) 2 Department of Pathology, Medical University of Vienna, Vienna 1090, Austria; andrea.beer@meduniwien.ac.at (A.B.); Koperek@labor-kaserer.at (O.K.); peter.birner@meduniwien.ac.at (P.B.) 3 Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna 1090, Austria; dietmar.tamandl@meduniwien.ac.at 4 Department of Surgery, Kaiser Franz Josef Hospital, Vienna 1100, Austria; thomas.gruenberger@gesundheitsverbund.at 5 Adaptive Biotechnologies Corporation, Seattle, WA 98102, USA; lkirsch@adaptivebiotech.com (I.K.); hrobins@adaptivebiotech.com (H.R.) 6 Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna, Vienna 1090, Austria; martina.mittlboeck@meduniwien.ac.at 7 Research Institute of Molecular Pathology, Vienna Biocenter, Vienna 1030, Austria; Markus.Jaritz@imp.ac.at 8 Department of Surgery, Medical University of Vienna, Vienna 1090, Austria; michael.bergmann@meduniwien.ac.at 9 Nebion AG, Zürich, 8048, Switzerland; phz@nebion.com * Correspondence: diana.mechtcheriakova@meduniwien.ac.at (D.M.); anastasia.meshcheryakova@meduniwien.ac.at (A.M.) † These authors contributed equally to this work. ‡ Current affiliation: Department of Surgery I, Rudolf Foundation Clinic, Vienna 1030, Austria. § Current affiliation: Clinical Pathology Laboratory Kaserer, Koperek and Beer, Vienna 1030, Austria.