Tissue distribution and clonal diversity of the T and B cell repertoire in type 1 diabetes

Howard R. Seay,1 Erik Yusko,2 Stephanie J. Rothweiler,1 Lin Zhang,1 Amanda L. Posgai,1 Martha Campbell-Thompson,1 Marissa Vignali,2 Ryan O. Emerson,2 John S. Kaddis,3 Dave Ko,3 Maki Nakayama,4 Mia J. Smith,5 John C. Cambier,5 Alberto Pugliese,6 Mark A. Atkinson,1 Harlan S. Robins,2,7 and Todd M. Brusko1 1Department of Pathology, Immunology and Laboratory Medicine, University of Florida Diabetes Institute, Gainesville, Florida, USA. 2Adaptive Biotechnologies Corporation, Seattle, Washington, USA. 3Department of Information Sciences, City of Hope National Medical Center, Duarte, California, USA. 4Barbara Davis Center for Childhood Diabetes and 5Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA. 6Diabetes Research Institute and Departments of Medicine, Microbiology, and Immunology, University of Miami Miller School of Medicine, Miami, Florida, USA. 7Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.