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TRAV1-2+ CD8+ T-cells including oligoconal expansions of MAIT cells are enriched in the airways in human tuberculosis

Wong et al.
Communications Biology
June 2019
Authors and Affiliates
Wong EB#1,2,3,4, Gold MC#5,6,7, Meermeier EW5, Xulu BZ1, Khuzwayo S1, Sullivan ZA1, Mahyari E8, Rogers Z1, Kløverpris H1,4,9, Sharma PK6, Worley AH6, Lalloo U10, Baijnath P10,11, Ambaram A11, Naidoo L11, Suleman M11,12, Madansein R13,14, McLaren JE15, Ladell K15, Miners KL15, Price DA15,16, Behar SM17, Nielsen M18,19, Kasprowicz VO1,20,21, Leslie A1,4, Bishai WR22, Ndung'u T1,19,20,21,23, Lewinsohn DM5,6,7. Author information 1 1Africa Health Research Institute, KwaZulu-Natal, South Africa. 2 2Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA USA. 3 3Harvard Medical School, Boston, MA USA. 4 4Division of Infection and Immunity, University College London, London, UK. 5 5Department of Pulmonary & Critical Care Medicine, Oregon Health & Science University, Portland, OR USA. 6 6VA Portland Health Care System, Portland, OR USA. 7 7Department of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, OR USA. 8 8Division of Bioinformatics and Computational Biology (BCB), Department of Medical Informatics and Clinical Epidemiology (DMICE), Oregon Health & Science University, Portland, OR USA. 9 9Institute for Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark. 10 10Durban University of Technology, Durban, South Africa. 11 Department of Pulmonology, Inkosi Albert Luthuli Hospital, Durban, South Africa. 12 12Department of Pulmonology & Critical Care, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa. 13 13Department of Cardiothoracic Surgery, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa. 14 14Centre for AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa. 15 15Institute of Infection & Immunity, Cardiff University School of Medicine, Cardiff, Wales UK. 16 16Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland USA. 17 17Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA USA. 18 18Center for Biological Sequence Analysis, Department of Bio and Health Informatics, Technical University of Denmark, Lyngby, Denmark. 19 19Instituto de Investigaciones Biotecnológicas, Universidad Nacional de San Martín, Buenos Aires, Argentina. 20 20HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa. 21 21The Ragon Institute of MGH, MIT, and Harvard, Harvard Medical School, Cambridge, MA USA. 22 22Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD USA. 23 23Max Planck Institute for Infection Biology, Berlin, Germany. # Contributed equally