Tumor response and endogenous immune reactivity after administration of HER2 CAR T cells in a child with metastatic rhabdomyosarcoma

Meenakshi Hegde 1,2,3, Sujith K Joseph 4,5,6, Farzana Pashankar 7, Christopher DeRenzo 4,5,6, Khaled Sanber 4,5,6,8, Shoba Navai 4,5,6, Tiara T Byrd 4,5,6, John Hicks 9, Mina L Xu 10, Claudia Gerken 4,5,6, Mamta Kalra 4,5,6, Catherine Robertson 5, Huimin Zhang 5, Ankita Shree 4,5,6, Birju Mehta 5, Olga Dakhova 5, Vita S Salsman 4,5,6, Bambi Grilley 4,5,6, Adrian Gee 4,5,6, Gianpietro Dotti 11,12, Helen E Heslop 4,5,6,8, Malcolm K Brenner 4,5,6,8, Winfried S Wels 13,14,15, Stephen Gottschalk 4,5,6,9, Nabil Ahmed 16,17,18,19; 1 Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA. mghegde@bcm.edu. 2 Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA. mghegde@bcm.edu. 3 Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. mghegde@bcm.edu. 4 Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA. 5 Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA. 6 Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. 7 Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA. 8 Department of Medicine, Baylor College of Medicine, Houston, TX, USA. 9 Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA. 10 Department of Pathology, Yale University School of Medicine, New Haven, CT, USA. 11 Department of Microbiology and Immunology at University of North Carolina, Chapel Hill, NC, USA. 12 Lineberger Cancer Center at University of North Carolina, Chapel Hill, NC, USA. 13 Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt, Germany. 14 German Cancer Consortium (DKTK), Partner Site Frankfurt/Mainz, Frankfurt, Germany. 15 Frankfurt Cancer Institute, Goethe University, Frankfurt, Germany. 16 Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA. 17 Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA. 18 Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. 19 Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA