New MRD Assessment Data Using clonoSEQ® To Be Presented at 2024 ASCO Annual Meeting and EHA2024 Hybrid Congress

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Perturbations of the T-cell receptor repertoire in response to SARS-CoV-2 in immunocompetent and immunocompromised individuals

Delmonte OM, et al.
Journal of Allergy and Clinical Immunology
January 2024
Authors and Affiliates
Ottavia M Delmonte 1, Cihan Oguz 2, Kerry Dobbs 3, Katherine Myint-Hpu 3, Boaz Palterer 3, Michael S Abers 3, Deborah Draper 3, Meng Truong 3, Ian M Kaplan 4, Rachel M Gittelman 4, Yu Zhang 3, Lindsey B Rosen 3, Andrew L Snow 5, Clifton L Dalgard 6, Peter D Burbelo 7, Luisa Imberti 8, Alessandra Sottini 8, Eugenia Quiros-Roldan 9, Francesco Castelli 9, Camillo Rossi 10, Duilio Brugnoni 11, Andrea Biondi 12, Laura Rachele Bettini 12, Mariella D'Angio' 12, Paolo Bonfanti 13, Megan V Anderson 14, Annalisa Saracino 15, Maria Chironna 16, Mariantonietta Di Stefano 17, Jose Ramon Fiore 17, Teresa Santantonio 17, Riccardo Castagnoli 18, Gian Luigi Marseglia 18, Mary Magliocco 19, Marita Bosticardo 3, Francesca Pala 3, Elana Shaw 3, Helen Matthews 19, Sarah E Weber 19, Sandhya Xirasagar 20, Jason Barnett 20, Andrew J Oler 20, Dimana Dimitrova 21, Jenna R E Bergerson 3, David H McDermott 22, V Koneti Rao 3, Philip M Murphy 22, Steven M Holland 3, Andrea Lisco 14, Helen C Su 3, Michail S Lionakis 3, Jeffrey I Cohen 23, Alexandra F Freeman 3, Thomas M Snyder 4, Justin Lack 2, Luigi D Notarangelo 24; 1 Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: ottavia.delmonte@nih.gov. 2 Integrated Data Sciences Section, Research Technology Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. 3 Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. 4 Adaptive Biotechnologies, Seattle, WA 98109, USA. 5 Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA; Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD 20892, USA. 6 Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA; The American Genome Center, Uniformed Services University of the Health Sciences, Bethesda, MD 20815, USA. 7 Adeno-Associated Virus Biology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA. 8 Section of Microbiology, University of Brescia, ASST Spedali Civili di Brescia, Brescia, Italy. 9 Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali Civili di Brescia, Brescia, Italy. 10 Direzione Sanitaria, ASST Spedali Civili di Brescia, Italy. 11 Laboratorio Analisi Chimico-Cliniche, ASST Spedali Civili, Brescia, Italy. 12 Pediatric Department and Centro Tettamanti-European Reference Network on Paediatric Cancer, European Reference Network on Haematological Diseases, and European Reference Network on Hereditary Metabolic Disorders-University of Milano-Bicocca-Fondazione MBBM, Monza, Italy. 13 Department of Infectious Diseases, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy. 14 Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. 15 Clinic of Infectious Diseases, Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari, University of Bari, Bari, Italy. 16 Hygiene Section, Department of Interdisciplinary Medicine, University of Bari Aldo Moro, Bari, Italy. 17 Department of Medical and Surgical Sciences, Section of Infectious Diseases, University of Foggia, Foggia, Italy. 18 Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy; Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. 19 Molecular Development of the Immune System Section, Laboratory of Immune System Biology, NIAID, NIH, Bethesda, MD 20892, USA. 20 Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. 21 Center for Immuno-Oncology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. 22 Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. 23 Laboratory of Infectious Diseases, National Institute of Allergy and Infectious diseases, National Institutes of Health, Bethesda, MD 20892, USA. 24 Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: luigi.notarangelo2@nih.gov.

Multistep tumor genetic evolution and changes in immunogenicity trigger immune-mediated disease eradication in stage IV melanoma: lessons from a single case

Vallacchi V, et al.
Journal for ImmunoTherapy of Cancer
January 2024
Authors and Affiliates
Viviana Vallacchi 1, Elisabetta Vergani 1, Mara Cossa 2, Chiara Gargiuli 3, Adele Busico 4, Andrea Devecchi 4, Matteo Dugo 5, Laura Bergamaschi 1, Loris De Cecco 6, Stefano Cavalieri 7,8, Barbara Valeri 2, Elena Tamborini 4, Gianfrancesco Gallino 9, Michele Del Vecchio 7, Mario Santinami 9, Marialuisa Sensi 3, Licia Rivoltini 1, Lorenza Di Guardo 7, Monica Rodolfo 10; 1 Department of Experimental Oncology, Unit of Translational Immunology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. 2 Pathology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. 3 Applied Research and Technology Development Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. 4 Department of Diagnostic Innovation, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. 5 Department of Medical Oncology, San Raffaele Hospital, Milan, Italy. 6 Integrated Biology of Rare Tumors, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. 7 Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. 8 Department of Oncology and Hemato-oncology, University of Milan, Milan, Italy. 9 Melanoma Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. 10 Department of Experimental Oncology, Unit of Translational Immunology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy monica.rodolfo@istitutotumori.mi.it.

ANHL1522: Durable Immunity to EBV post Rituximab and Third Party LMP-specific T-cells: A Children’s Oncology Group Study

Wistinghausen B, et al.
Blood Advances
January 2024
Authors and Affiliates
Birte Wistinghausen 1, Keri Toner 2, Donald A Barkauskas 3, Lauren P Jerkins 4, Hannah Kinoshita 5, Pamela Chansky 6, Gloria Pezzella 7, Lauren Saguilig 4, Robert J Hayashi 8, Harshal A Abhyankar 9, Brooks Scull 10, Vivekanudeep Karri 10, Jay Tanna 5, Patrick J Hanley 1, Michelle L Hermiston 11, Carl E Allen 10, Catherine M Bollard 4; 1 Children's National Medical Center, Washington, District of Columbia, United States. 2 Children's National Health System, Washington, District of Columbia, United States. 3 University of Southern California, United States. 4 Children's National Hospital, United States. 5 Childrens National Medical Center, Washington, District of Columbia, United States. 6 The George Washington University School of Medicine and Health Sciences, United States. 7 Children's National Hospital, Washington, District of Columbia, United States. 8 Washington University in St. Louis School of Medicine, St. Louis, Missouri, United States. 9 Baylor College Of Medicine, Houston, Texas, United States. 10 Baylor College of Medicine, Houston, Texas, United States. 11 University of California, San Francisco, San Francisco, California, United States.

Discovery of U2AF1 neoantigens in myeloid neoplasms

Biernacki MA, et al.
Journal for ImmunoTherapy of Cancer
January 2024
Authors and Affiliates
Melinda Ann Biernacki 1,2, Jessica Lok 3, Ralph Graeme Black 3, Kimberly A Foster 4, Carrie Cummings 3, Kyle B Woodward 3, Tim Monahan 3, Vivian G Oehler 3,2, Derek L Stirewalt 3,2, David Wu 5, Anthony Rongvaux 3, Hans Joachim Deeg 3,2, Marie Bleakley 3,6; 1 Translational Sciences and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA mbiernac@fredhutch.org. 2 Department of Medicine, University of Washington, Seattle, Washington, USA. 3 Translational Sciences and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA. 4 Department of Immunology, University of Washington, Seattle, Washington, USA. 5 Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA. 6 Department of Pediatrics, University of Washington, Seattle, Washington, USA.

NKG2D receptor signaling shapes T cell thymic education

Perez C, et al.
journal of leukocyte biology
December 2023
Authors and Affiliates
Cynthia Perez 1, Lourdes Plaza-Rojas 2, Justin C Boucher 2, Mate Z Nagy 2, Elena Kostenko 2, Kushal Prajapati 1, Brianna Burke 1, Michael Delos Reyes 1, Anna L Austin 2, Shubin Zhang 1,3, Phong T Le 1,3, José A Guevara-Patino 1,2; 1 Department of Cancer Biology, Loyola University Chicago, 2160 S. First Ave, Maywood, IL 60153, United States. 2 Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, United States. 3 Department of Microbiology and Immunology, Loyola University Chicago, 2160 S. First Ave, Maywood, IL 60153, United States.

Exploratory analysis of the cervix tumoral HPV antigen-specific T-cell repertoire during chemoradiation and after brachytherapy

Manzar GS, et al.
Brachytherapy
December 2023
Authors and Affiliates
Gohar S Manzar 1, Molly B El Alam 1, Erica J Lynn 1, Tatiana V Karpinets 2, Timothy Harris 1, David Lo 1, Kyoko Yoshida-Court 1, Tatiana Cisneros Napravnik 1, Julie Sammouri 1, Daniel Lin 1, Lauren M Andring 1, Julianna Bronk 1, Xiaogang Wu 2, Travis T Sims 3, Geena Mathew 1, Kathleen M Schmeler 3, Patricia J Eifel 1, Anuja Jhingran 1, Lilie L Lin 1, Melissa M Joyner 1, Jianhua Zhang 2, Andrew Futreal 2, Ann H Klopp 1, Lauren E Colbert 4; 1 Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX. 2 Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX. 3 Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX. 4 Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address: lcolbert@mdanderson.org.

The Cyclin D3 Protein Enforces Monogenic TCRβ Expression by Mediating TCRβ Protein-Signaled Feedback Inhibition of Vβ Recombination

Culberson EJ, at al.
Journal of Immunology
December 2023
Authors and Affiliates
Erica J Culberson 1, Kymberle C Shields 1, Rebecca A Glynn 1,2, Brittney M Allyn 1,3, Katharina E Hayer 1,4,5, Craig H Bassing 1,2,3; 1 Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. 2 Cell and Molecular Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. 3 Immunology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. 4 Biomedical Engineering Doctoral Degree Program, School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA. 5 Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Perelman School of Medicine, Philadelphia, PA.

TCRseq Reveals Selected Donor-reactive CD8+ T cell Clones Resist Anti-Thymocyte Globulin Depletion after Kidney Transplantation

Ningoo M, et al.
American Journal of Transplantation
December 2023
Authors and Affiliates
Mehek Ningoo 1, Pamela Cruz-Encarnación 1, Calla Khilnani 1, Peter S Heeger 2, Miguel Fribourg 3; 1 Translational Transplant Research Center, Division of Nephrology, Department of Medicine; Immunology Institute Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. 2 Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA. 3 Translational Transplant Research Center, Division of Nephrology, Department of Medicine; Immunology Institute Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: miguel.fribourg@mssm.edu.

The ERK inhibitor LY3214996 augments anti-PD-1 immunotherapy in preclinical mouse models of BRAFV600E melanoma brain metastasis

de Sauvage MA, at al.
neuro-oncology
December 2023
Authors and Affiliates
Magali A de Sauvage 1,2, Consuelo Torrini 1, Edwin Nieblas-Bedolla 1, Elizabeth Summers 1, Emily Sullivan 1, Britney S Zhang 1, Emily Batchelor 1, Braxton Marion 1, Erika Yamazawa 1, Samuel C Markson 3,4, Hiroaki Wakimoto 1, Naema Nayyar 1, Priscilla Brastianos 1,5; 1 Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA. 2 University of Utah School of Medicine, Salt Lake City, UT, USA. 3 Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA. 4 Broad Institute of MIT and Harvard, Cambridge, MA, USA. 5 Division of Hematology/Oncology and Neuro-Oncology, Department of Medicine & Neurology, Massachusetts General Hospital. Boston, MA.

Identification of unstable regulatory and autoreactive effector T cells that are expanded in patients with FOXP3 mutations

Borna S, et al.
Science Translational Medicine
December 2023
Authors and Affiliates
Šimon Borna 1, Esmond Lee 1,2, Jason Nideffer 1, Akshaya Ramachandran 1, Bing Wang 1, Jeanette Baker 3, Melissa Mavers 1, Uma Lakshmanan 1, Mansi Narula 1, Amy Kang-Hee Garrett 1, Janika Schulze 4, Sven Olek 5, Louis Marois 6, Yael Gernez 7, Monica Bhatia 8, Hey Jin Chong 9, Jolan Walter 10, Maleewan Kitcharoensakkul 11, Abigail Lang 12,13, Megan A Cooper 14, Alice Bertaina 1,15, Maria Grazia Roncarolo 1,2,15, Eric Meffre 16, Rosa Bacchetta 1,15; 1 Department of Pediatrics, Division of Hematology, Oncology, Stem Cell Transplantation and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. 2 Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. 3 Department of Medicine, Division of Blood and Marrow Transplantation, Stanford University School of Medicine, Stanford, CA 94305, USA. 4 Epimune GmbH, Berlin 12489, Germany. 5 Ivana Turbachova Laboratory for Epigenetics, Precision for Medicine GmbH, Berlin 12489, Germany. 6 Department of Medicine, Immunology and Allergy Service, CHU de Québec-Laval University, Quebec G1V 4G2, Canada. 7 Department of Pediatrics, Division of Allergy, Rheumatology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA. 8 Columbia University Irving Medical Center, New York, NY 10032, USA. 9 Division of Allergy and Immunology, University of Pittsburgh Medical Center Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA. 10 Division of Allergy and Immunology, Department of Pediatrics, Johns Hopkins All Children's Hospital, University of South Florida, St. Petersburg, FL 33701, USA. 11 Divisions of Rheumatology/Immunology and Allergy and Pulmonary Medicine, Department of Pediatrics, Washington University in St. Louis, St. Louis, MO 63110, USA. 12 Department of Pediatrics, Division of Allergy and Immunology, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL 60611, USA. 13 Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. 14 Department of Pediatrics, Division of Rheumatology and Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA. 15 Center for Definitive and Curative Medicine (CDCM), Stanford University School of Medicine, Stanford, CA 94305, USA. 16 Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, 269 Campus Drive West, Stanford, CA 94305, USA.