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Human Intestinal Allografts Contain Functional Hematopoietic Stem and Progenitor Cells that Are Maintained by a Circulating Pool

Fu et al.
Cell Stem Cell
February 2019
Authors and Affiliates
Fu J1, Zuber J1, Martinez M2, Shonts B1, Obradovic A1, Wang H1, Lau SP1, Xia A1, Waffarn EE1, Frangaj K1, Savage TM1, Simpson MT1, Yang S1, Guo XV3, Miron M4, Senda T5, Rogers K1, Rahman A3, Ho SH1, Shen Y6, Griesemer A5, Farber DL7, Kato T8, Sykes M9. 1 Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY 10032, USA. 2 Department of Pediatrics, Columbia University, New York, NY 10032, USA. 3 Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. 4 Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY 10032, USA; Department of Microbiology & Immunology, Columbia University, New York, NY 10032, USA. 5 Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY 10032, USA; Department of Surgery, Columbia University, New York, NY 10032, USA. 6 Center for Computational Biology and Bioinformatics, Department of Systems Biology, Columbia University, New York, NY 10032, USA. 7 Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY 10032, USA; Department of Microbiology & Immunology, Columbia University, New York, NY 10032, USA; Department of Surgery, Columbia University, New York, NY 10032, USA. 8 Department of Surgery, Columbia University, New York, NY 10032, USA. 9 Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY 10032, USA; Department of Microbiology & Immunology, Columbia University, New York, NY 10032, USA; Department of Surgery, Columbia University, New York, NY 10032, USA. Electronic address: megan.sykes@columbia.edu.

High frequency of shared clonotypes in human B cell receptor repertoires

Soto et al.
Nature
February 2019
Authors and Affiliates
Soto C1,2, Bombardi RG1, Branchizio A1, Kose N1, Matta P1, Sevy AM3, Sinkovits RS4, Gilchuk P1, Finn JA3, Crowe JE Jr5,6,7. 1 The Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA. 2 Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA. 3 Chemical and Physical Biology Program, Vanderbilt University, Nashville, TN, USA. 4 San Diego Supercomputer Center, University of California, San Diego, San Diego, CA, USA. 5 The Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA. james.crowe@vanderbilt.edu. 6 Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA. james.crowe@vanderbilt.edu. 7 Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA. james.crowe@vanderbilt.edu.

Altered T Cell Receptor Beta Repertoire Patterns in Pediatric Ulcerative Colitis

Werner et al.
Clinical and Experimental Immunology
January 2019
Authors and Affiliates
Werner L1,2, Nunberg MY1,2, Rechavi E2,3,4,5, Lev A2,3,4,5, Braun T1,2, Haberman Y1,2, Lahad A1,2, Shteyer E6, Schvimer M7, Somech R2,3,4,5, Weiss B1,2, Lee YN2,3,4,5, Shouval DS1,2. 1 Pediatric Gastroenterology Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel. 2 Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. 3 Pediatric Department A, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel. 4 Immunology Service, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel. 5 Jeffrey Modell Foundation Center, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel. 6 Juliet Keidan Institute of Pediatric Gastroenterology, Hepatology and Nutrition, Shaare Zedek Medical Center and The Hebrew University of Jerusalem, Jerusalem, Israel. 7 Institute of Pathology, Sheba Medical Center, Tel Hashomer, Israel.

Cytomegalovirus Exposure in the Elderly Does Not Reduce CD8 T Cell Repertoire Diversity

Lindau et al.
Journal of Immunology
January 2019
Authors and Affiliates
Lindau P1,2, Mukherjee R3, Gutschow MV2, Vignali M4, Warren EH5,6, Riddell SR5,6, Makar KW7, Turtle CJ5,6, Robins HS8,4 1 Molecular and Cellular Biology Graduate Program, University of Washington School of Medicine, Seattle, WA 98195; plindau@uw.edu hrobins@fredhutch.org. 2 Herbold Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109. 3 Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA 98101. 4 Adaptive Biotechnologies, Seattle, WA 98102. 5 Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109. 6 Department of Medicine, University of Washington, Seattle, WA 98195; and. 7 Bill and Melinda Gates Foundation, Seattle, WA 98109. 8 Herbold Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109; plindau@uw.edu hrobins@fredhutch.org.

Tumor-infiltrating human CD4 regulatory Tcells display a distinct TCR repertoire and exhibit tumor and neoantigen reactivity

Ahmadzadeh et al.
Science Immunology
January 2019
Authors and Affiliates
Ahmadzadeh M1, Pasetto A1, Jia L1, Deniger DC1, Stevanović S2, Robbins PF1, Rosenberg SA3. 1 Surgery Branch, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USA. 2 Experimental Transplantation and Immunology Branch, NCI, NIH, Bethesda, MD 20892, USA. 3 Surgery Branch, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USA.

Benign T cells drive clinical skin inflammation in cutaneous T cell lymphoma

Vieyra-Garcia et al.
JCI Insight
January 2019
Authors and Affiliates
Vieyra-Garcia P1,2, Crouch JD1, O'Malley JT1, Seger EW1, Yang CH1, Teague JE1, Vromans AM1, Gehad A1, Win TS1, Yu Z3, Lowry EL1, Na JI1,4, Rook AH5, Wolf P2, Clark RA1 1 Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. 2 Research Unit for Photodermatology, Department of Dermatology and Venereology, Medical University of Graz, Graz, Austria. 3 Harvard Medical School, Boston, Massachusetts, USA. 4 Department of Dermatology, Seoul National University Bundang Hospital, Seongnam, South Korea. 5 Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

A multifactorial model of T cell expansion and durable clinical benefit in response to a PD-L1 inhibitor

Leiserson et al.
PLOS ONE
December 2018
Authors and Affiliates
Leiserson MDM1,2, Syrgkanis V1, Gilson A1, Dudik M3, Gillett S1, Chayes J1,3, Borgs C1, Bajorin DF4,5, Rosenberg JE4, Funt S4,5, Snyder A4,6, Mackey L1; 1 Microsoft Research New England, Cambridge, MA, United States of America. 2 University of Maryland, College Park, Department of Computer Science, College Park, MD, United States of America. 3 Microsoft Research New York, New York, NY, United States of America. 4 Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, United States of America. 5 Department of Medicine, Weill Cornell Medical College, New York, NY, United States of America. 6 Adaptive Biotechnologies, Seattle, WA, United States of America

Radiotherapy induces responses of lung cancer to CTLA-4 blockade

Formenti et al.
Nature Medicine
December 2018
Authors and Affiliates
Formenti SC1, Rudqvist NP2, Golden E2,3, Cooper B4, Wennerberg E2, Lhuillier C2, Vanpouille-Box C2, Friedman K5, Ferrari de Andrade L6,7, Wucherpfennig KW6,7, Heguy A8,9, Imai N10, Gnjatic S10, Emerson RO11, Zhou XK12, Zhang T13, Chachoua A14, Demaria S15,16. 1 Department of Radiation Oncology, Weill Cornell Medicine, New York, NY, USA. formenti@med.cornell.edu. 2 Department of Radiation Oncology, Weill Cornell Medicine, New York, NY, USA. 3 Department of Radiation Oncology, University of California, San Francisco, CA, USA. 4 Department of Radiation Oncology, New York University School of Medicine, New York, NY, USA. 5 Department of Radiology, New York University School of Medicine, New York, NY, USA. 6 Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA. 7 Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, USA. 8 Department of Pathology, New York University School of Medicine, New York, NY, USA. 9 Genome Technology Center, Division of Advanced research Technologies, NYU Langone Health, New York, NY, USA. 10 Tisch Cancer Institute, Hematology/Oncology, Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 11 Adaptive Biotechnologies, Seattle, WA, USA. 12 Division of Biostatistics and Epidemiology, Department of Healthcare Policy and Research, Weill Cornell Medicine, New York, NY, USA. 13 Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA. 14 Department of Medicine, New York University School of Medicine, New York, NY, USA. 15 Department of Radiation Oncology, Weill Cornell Medicine, New York, NY, USA. szd3005@med.cornell.edu. 16 Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA. szd3005@med.cornell.edu.

Human retinoic acid–regulated CD161+ regulatory T cells support wound repair in intestinal mucosa

Povoleri et al.
Nature Immunology
December 2018
Authors and Affiliates
Povoleri GAM1,2, Nova-Lamperti E1,2, Scottà C1,2, Fanelli G1,2, Chen YC3, Becker PD1,2, Boardman D1,2, Costantini B4, Romano M1,2, Pavlidis P1,2, McGregor R1,2, Pantazi E1,2, Chauss D5, Sun HW6, Shih HY7, Cousins DJ8, Cooper N9, Powell N1,2, Kemper C10, Pirooznia M3, Laurence A11, Kordasti S4, Kazemian M12, Lombardi G1,2, Afzali B13,14,15 1 MRC, Centre for Transplantation, King's College London, London, UK. 2 National Institute for Health Research Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust and King's College London, London, UK. 3 Bioinformatics and Computational Biology Core, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA. 4 Comprehensive Cancer Centre, School of Cancer and Pharmaceutical Sciences, King's College London, London, UK. 5 Immunoregulation Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA. 6 Biodata Mining and Discovery Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA. 7 Lymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA. 8 Department of Infection, Immunity and Inflammation, NIHR Leicester Respiratory Biomedical Research Unit, University of Leicester, Leicester, UK. 9 Department of Medicine, Imperial College London, London, UK. 10 Complement and Inflammation Research Section, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA. 11 Institute of Cellular Medicine, Newcastle University, Newcastle, UK. 12 Departments of Biochemistry and Computer Science, Purdue University, West Lafayette, IN, USA. 13 MRC, Centre for Transplantation, King's College London, London, UK. behdad.afzali@nih.gov. 14 Immunoregulation Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA. behdad.afzali@nih.gov. 15 National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA. behdad.afzali@nih.gov.
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