ASH 2023: MRD Highlights in BioPharma Drug Development

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Safety and pharmacokinetics of imaradenant (AZD4635) in Japanese patients with advanced solid malignancies: a phase I, open-label study

Matsubara N, et al.
December 2023
Authors and Affiliates
Nobuaki Matsubara 1, Shota Kusuhara 2, Noboru Yamamoto 3, Kazuki Sudo 3, Masahiko Yanagita 4,5, Kosho Murayama 6, Hisashi Kawasumi 4, Deanna L Russell 7, Da Yin 8, Toshio Shimizu 3,9; 1 Department of Medical Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan. nmatsuba@east.ncc.go.jp. 2 Department of Medical Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan. 3 Department of Experimental Therapeutics, National Cancer Center Hospital, Tokyo, Japan. 4 Research & Development, AstraZeneca K.K., Tokyo, Japan. 5 Oncology Medical Affairs, Pfizer Japan Inc., Tokyo, Japan. 6 Research & Development, AstraZeneca K.K., Osaka, Japan. 7 Translational Medicine, Early Oncology, Oncology R&D, AstraZeneca Pharmaceuticals, Boston, MA, USA. 8 Oncology Data Science, Research and Early Development, Oncology R&D, AstraZeneca Pharmaceuticals, Gaithersburg, MD, USA. 9 Department of Pulmonary Medicine and Medical Oncology, Wakayama Medical University Graduate School of Medicine, Wakayama Medical University Hospital, Wakayama, Japan.

Plasticity of intragraft alloreactive T cell clones in human gut correlates with transplant outcomes

Fu J, et al.
Journal of Experimental Medicine
December 2023
Authors and Affiliates
Jianing Fu 1, Zicheng Wang 2, Mercedes Martinez 3, Aleksandar Obradovic 1, Wenyu Jiao 1, Kristjana Frangaj 1, Rebecca Jones 1, Xinzheng V Guo 4, Ya Zhang 4, Wan-I Kuo 4, Huaibin M Ko 5, Alina Iuga 5, Constanza Bay Muntnich 1, Adriana Prada Rey 1, Kortney Rogers 1, Julien Zuber 1, Wenji Ma 2, Michelle Miron 6, Donna L Farber 6,7, Joshua Weiner 1,7, Tomoaki Kato 7, Yufeng Shen 2, Megan Sykes 1,6,7; 1 Department of Medicine, Columbia Center for Translational Immunology, Columbia University, New York, NY, USA. 2Department of Systems Biology, Center for Computational Biology and Bioinformatics, Columbia University, New York, NY, USA. 3 Department of Pediatrics, Columbia University, New York, NY, USA. 4 Human Immune Monitoring Core, Herbert Irving Comprehensive Cancer Center, Columbia University , New York, NY, USA. 5 Department of Pathology and Cell Biology, Columbia University, New York, NY, USA. 6 Department of Microbiology and Immunology, Columbia University, New York, NY, USA. 7 Department of Surgery, Columbia University, New York, NY, USA.

Repeated mRNA vaccination sequentially boosts SARS-CoV-2-specific CD8+ T cells in persons with previous COVID-19

Ford ES, et al.
Nature Immunology
December 2023
Authors and Affiliates
Emily S Ford 1,2, Koshlan Mayer-Blackwell 2, Lichen Jing 1, Kerry J Laing 1, Anton M Sholukh 2, Russell St Germain 2, Emily L Bossard 2, Hong Xie 3, Thomas H Pulliam 1, Saumya Jani 1,3, Stacy Selke 3, Carlissa J Burrow 1, Christopher L McClurkan 1, Anna Wald 1,2,3,4, Alexander L Greninger 2,3, Michael R Holbrook 5, Brett Eaton 5, Elizabeth Eudy 5, Michael Murphy 5, Elena Postnikova 5, Harlan S Robins 6, Rebecca Elyanow 6, Rachel M Gittelman 6,7, Matyas Ecsedi 8,9, Elise Wilcox 8, Aude G Chapuis 1,8, Andrew Fiore-Gartland 2, David M Koelle 10,11,12,13,14; 1 Department of Medicine, University of Washington, Seattle, WA, USA. 2 Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA. 3 Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA. 4 Department of Epidemiology, University of Washington, Seattle, WA, USA. 5 Integrated Research Facility, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, MD, USA. 6 Adaptive Biotechnologies, Seattle, WA, USA. 7 Guardant Health, Redwood City, CA, USA. 8 Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA, USA. 9 Takeda Oncology, Cambridge, MA, USA. 10 Department of Medicine, University of Washington, Seattle, WA, USA. 11 Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA. 12 Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA. 13 Department of Global Health, University of Washington, Seattle, WA, USA. 14 Department of Translational Research, Benaroya Research Institute, Seattle, WA, USA. dkoelle@medicine.washington.edu.

Phenotypic signatures of circulating neoantigen-reactive CD8+ T cells in patients with metastatic cancers

Yossef R, et al.
Cancer Cell
December 2023
Authors and Affiliates
Rami Yossef 1, Sri Krishna 2, Sivasish Sindiri 3, Frank J Lowery 3, Amy R Copeland 3, Jared J Gartner 3, Maria R Parkhurst 3, Neilesh B Parikh 3, Kyle J Hitscherich 3, Shoshana T Levi 3, Praveen D Chatani 3, Nikolaos Zacharakis 3, Noam Levin 3, Nolan R Vale 3, Shirley K Nah 3, Aaron Dinerman 3, Victoria K Hill 3, Satyajit Ray 3, Alakesh Bera 3, Lior Levy 3, Li Jia 4, Michael C Kelly 5, Stephanie L Goff 3, Paul F Robbins 3, Steven A Rosenberg 6; 1 Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: yosef.rami@gmail.com. 2 Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: sri.krishna@nih.gov. 3 Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. 4 National Institutes of Health Library, National Institutes of Health, Bethesda, MD 20892, USA. 5 Single Cell Analysis Facility, Cancer Research Technology Program, Frederick National Laboratory, Bethesda, MD 20892, USA. 6 Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: sar@nih.gov.

SARS-CoV-2 specific immune responses in overweight and obese COVID-19 patients

Onyango TB, et al.
Frontiers in Immunology
December 2023
Authors and Affiliates
Therese Bredholt Onyango 1, Fan Zhou 1, Geir Bredholt 2, Karl A Brokstad 1,3, Sarah Lartey 1, Kristin G-I Mohn 1,4, Türküler Özgümüs 5, Bård Reiakvam Kittang 6, Dagrun Waag Linchausen 7, Shahin Shafiani 8, Rebecca Elyanow 8, Bjørn Blomberg 2,4,9, Nina Langeland 2,4,9, Rebecca Jane Cox 1,10; Bergen COVID-19 Research Group; 1 Influenza Centre, Department of Clinical Science, University of Bergen, Bergen, Norway. 2 Department of Clinical Science, University of Bergen, Bergen, Norway. 3 Department of Safety, Chemistry and Biomedical Laboratory Sciences, Western Norway University of Applied Sciences, Bergen, Norway. 4 Department of Medicine, Haukeland University Hospital, Bergen, Norway. 5 Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway. 6 Department of Medicine, Haraldsplass Deaconess Hospital, Bergen, Norway. 7 Bergen Municipality Emergency Clinic, Bergen, Norway. 8 Adaptive Biotechnologies, Seattle, WA, United States. 9 National Advisory Unit for Tropical Infectious Diseases, Haukeland University Hospital, Bergen, Norway. 10 Department of Microbiology, Haukeland University Hospital, Bergen, Norway.

Core Needle Biopsies as an Alternative Source for Ex Vivo Expanded TIL for Adoptive Cell Therapy in Triple-Negative Breast Cancer

Coman MM, et al.
Journal of Immunotherapy
December 2023
Authors and Affiliates
Magdalena M Coman 1, Lajos Pusztai 2, Regina Hooley 3, Liva Andreveja 3, Leah Kim 1, Nikhil Joshi 4, Alexey Bersenev 5, Diane Krause 5, Tristen S Park 1; 1 Department of Surgery, Yale School of Medicine, Yale University, New Haven, CT. 2 Department of Medicine, Yale Cancer Center, Yale University, New Haven, CT. 3 Department of Radiology and Biomedical Imaging, Yale School of Medicine, Yale University, New Haven, CT. 4 Department of Immunobiology, Yale Cancer Center, Yale University School of Medicine, New Haven, CT. 5 Department of Laboratory Medicine and Pathology, Yale School of Medicine, New Haven, CT.

Multimodal, broadly neutralizing antibodies against SARS-CoV-2 identified by high-throughput native pairing of BCRs from bulk B cells

Keitany GJ, et al.
Cell Chemical Biology
December 2023
Authors and Affiliates
Gladys J Keitany 1, Benjamin E R Rubin 1, Meghan E Garrett 1, Andrea Musa 1, Jeff Tracy 1, Yu Liang 1, Peter Ebert 1, Amanda J Moore 1, Jonathan Guan 1, Erica Eggers 1, Ninnia Lescano 1, Ryan Brown 1, Adria Carbo 1, Hussein Al-Asadi 1, Travers Ching 1, Austin Day 1, Rebecca Harris 1, Charles Linkem 1, Dimitry Popov 1, Courtney Wilkins 1, Lianqu Li 2, Jiao Wang 2, Chuanxin Liu 2, Li Chen 2, Jennifer N Dines 1, Caroline Atyeo 3, Galit Alter 3, Lance Baldo 1, Anna Sherwood 1, Bryan Howie 1, Mark Klinger 1, Erik Yusko 1, Harlan S Robins 1, Sharon Benzeno 1, Amy E Gilbert 4; 1 Adaptive Biotechnologies, Seattle, WA 98109, USA. 2 GenScript ProBio Biotech, Nanjing, Jiangsu Province, China. 3 Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA. 4 Adaptive Biotechnologies, Seattle, WA 98109, USA. Electronic address: agilbert@adaptivebiotech.com.

Phototherapy Restores Deficient Type I IFN Production and Enhances Antitumor Responses in Mycosis Fungoides

Yu Z, et al.
Journal of Investigative Dermatology
December 2023
Authors and Affiliates
Zizi Yu 1, Pablo Vieyra-Garcia 2, Theresa Benezeder 2, Jack D Crouch 1, Ira R Kim 1, John T O'Malley 1, Phillip M Devlin 3, Ahmed Gehad 1, Qian Zhan 1, Johann E Gudjonsson 4, Mrinal K Sarkar 4, J Michelle Kahlenberg 5, Nega Gerard 1, Jessica E Teague 1, Thomas S Kupper 6, Nicole R LeBoeuf 6, Cecilia Larocca 6, Marianne Tawa 7, Bohdan Pomahac 8, Simon G Talbot 9, Dennis P Orgill 9, Peter Wolf 10, Rachael A Clark 11; 1 Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. 2 Research Unit for Photodermatology, Department of Dermatology and Venereology, Medical University of Graz, Graz, Austria. 3 Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and Women's Cancer Center, Harvard Medical School, Boston, Massachusetts, USA. 4 Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA. 5 Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA. 6 Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA; Center for Cutaneous Oncology, Dana-Farber Cancer Institute/Brigham and Women's Cancer Center, Harvard Medical School, Boston, Massachusetts, USA. 7 Center for Cutaneous Oncology, Dana-Farber Cancer Institute/Brigham and Women's Cancer Center, Harvard Medical School, Boston, Massachusetts, USA. 8 Division of Plastic and Reconstructive Surgery, Department of Surgery, Yale School of Medicine, New Haven, Connecticut, USA. 9 Division of Plastic and Reconstructive Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. 10 Research Unit for Photodermatology, Department of Dermatology and Venereology, Medical University of Graz, Graz, Austria. Electronic address: peter.wolf@medunigraz.at. 11 Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. Electronic address: rclark@bwh.harvard.edu.

Daratumumab, Bortezomib, Lenalidomide, and Dexamethasone for Multiple Myeloma.

Sonneveld P, et al.
New England Journal of Medicine
December 2023
Authors and Affiliates
Pieter Sonneveld, Meletios A Dimopoulos, Mario Boccadoro, Hang Quach, P Joy Ho, Meral Beksac, Cyrille Hulin, Elisabetta Antonioli, Xavier Leleu, Silvia Mangiacavalli, Aurore Perrot, Michele Cavo, Angelo Belotti, Annemiek Broijl, Francesca Gay, Roberto Mina, Inger S Nijhof, Niels W C J van de Donk, Eirini Katodritou, Fredrik Schjesvold, Anna Sureda Balari, Laura Rosiñol, Michel Delforge, Wilfried Roeloffzen, Tobias Silzle, Annette Vangsted, Hermann Einsele, Andrew Spencer, Roman Hajek, Artur Jurczyszyn, Sarah Lonergan, Tahamtan Ahmadi, Yanfang Liu, Jianping Wang, Diego Vieyra, Emilie M J van Brummelen, Veronique Vanquickelberghe, Anna Sitthi-Amorn, Carla J de Boer, Robin Carson, Paula Rodriguez-Otero, Joan Bladé, Philippe Moreau; PERSEUS Trial Investigators
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