A critical insulin TCR contact residue selects high affinity and pathogenic insulin specific T cells

Maria Bettini,1,2,7 Marissa A. Scavuzzo,4,6 Baoyu Liu,5 Elizabeth Kolawole,5 Lin Guo,1 Brian D. Evavold,5 Malgorzata Borowiak2,3,4 and Matthew L. Bettini1,2,7 1Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030 2 USA. 3 4 5Division of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT 84112 6 Present address: Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH, 44106 USA 7Present address: Division of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT 84112