Abnormalities of T-cell receptor repertoire in CD4+ regulatory and conventional T cells in patients with RAG mutations: Implications for autoimmunity

Jared H. Rowe, MD, PhDa, Brian D. Stadinski, PhDb, Lauren A. Henderson, MDa, Lisa Ott de Bruin, MDa, Ottavia Delmonte, MDa, Yu Nee Lee, PhDc, M. Teresa de la Morena, MDd, Rakesh K. Goyal, MDe, Anthony Hayward, MD, PhDf, Chiung-Hui Huang, PhDg, Maria Kanariou, MDh, Alejandra King, MDi, Taco W. Kuijpers, MDj, Jian Yi Soh, MDg, Benedicte Neven, MD, PhDk, Jolan E. Walter, MD, PhDl, Eric S. Huseby, PhDb, Luigi D. Notarangelo, MDm aThe Division of Immunology, Boston Children’s Hospital, Boston, Mass; bthe Department of Pathology, University of Massachusetts Medical School, Worcester, Mass; cthe Pediatric Department A and the Immunology Service, ‘‘Edmond and Lily Safra’’ Children’s Hospital, Jeffrey Modell Foundation Center, Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; dthe Division of Allergy and Immunology, University of Texas, Southwestern Medical Center, Dallas, Tex; ethe Division of Hematology/Oncology/BMT, Children’s Mercy Hospital & Clinics, Kansas City, Mo; fthe Department of Pediatrics, Brown University, Providence, RI; gthe Department of Pediatrics, National University of Singapore, Singapore; hthe Department of Immunology-Histocompatibility, ‘‘Aghia Sophia’’ Children’s Hospital, Athens, Greece; ithe Division of Pediatric Immunology, Hospital Luis Calvo Mackenna, Santiago, Chile; jthe Department of Pediatric Hematology, Immunology and Infectious Diseases, Emma Children’s Hospital, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; kthe Pediatric Hematology-Immunology Department, Hospital Necker-Enfants Malades, AP-HP, Paris Descartes University, Sorbonne-Paris-Cite, Institut Imagine, Paris, France; lthe Division of Pediatric Allergy/Immunology, University of South Florida at Johns Hopkins All Children’s Hospital, St Petersburg, Fla; and mthe Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.