Adaptive plasticity of IL-10+ and IL-35+ Treg cells cooperatively promotes tumor T cell exhaustion
Sawant et al.
Nature Immunology
April 2019
Authors and Affiliates
Sawant DV1,2, Yano H1,3, Chikina M4, Zhang Q1,5, Liao M1,6, Liu C1, Callahan DJ1,3, Sun Z7, Sun T7, Tabib T8, Pennathur A9, Corry DB10, Luketich JD9, Lafyatis R8, Chen W7, Poholek AC1,11, Bruno TC1,12,13, Workman CJ1, Vignali DAA14,15,16; 1
Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
2
Department of Inflammation and Oncology, Discovery Research, Amgen, South San Francisco, CA, USA.
3
Program in Microbiology and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
4
Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
5
Evergrande Center for Immunologic Diseases and Ann Romney Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA.
6
The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
7
Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh, PA, USA.
8
Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
9
Department of Cardiothoracic Surgery, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
10
Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
11
Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
12
Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
13
Cancer Immunology & Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
14
Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. dvignali@pitt.edu.
15
Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA. dvignali@pitt.edu.
16
Cancer Immunology & Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA. dvignali@pitt.edu.