An intra-tumoral niche maintains and differentiates stem-like CD8 T cells

Caroline S. Jansen1, Nataliya Prokhnevska1, Viraj A. Master1,2, Martin G. Sanda1,2, Jennifer W. Carlisle2,3, Mehmet Asim Bilen2,3, Maria Cardenas1, Scott Wilkinson4, Ross Lake4, Adam G. Sowalsky4, Rajesh M. Valanparambil5,6, William H. Hudson5,6, Donald McGuire5,6, Kevin Melnick1, Amir I. Khan1, Kyu Kim1, Yun Min Chang5, Alice Kim1, Christopher P. Filson1,2, Mehrdad Alemozaffar1,2, Adeboye O. Osunkoya1,2,7, Patrick Mullane7, Carla Ellis7, Rama Akondy5,6, Se Jin Im5,6, Alice O. Kamphorst8, Adriana Reyes1, Yuan Liu2,9 & Haydn Kissick1,2,5,6* 1Department of Urology, Emory University School of Medicine, Atlanta, GA, USA. 2Winship Cancer Institute of Emory University, Atlanta, GA, USA. 3Department of Hematology and Oncology, Emory University School of Medicine, Atlanta, GA, USA. 4Laboratory of Genitourinary Cancer Pathogenesis, National Cancer Institute, Bethesda, MD, USA. 5Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA. 6Emory Vaccine Centre, Emory University School of Medicine, Atlanta, GA, USA. 7Department of Pathology, Emory University School of Medicine, Atlanta, GA, USA. 8Department of Oncological Sciences, Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York City, NY, USA. 9Rollins School of Public Health, Emory University, Atlanta, GA, USA. *e-mail: haydn.kissick@emory.edu