CD1b Tetramers Identify T Cells that Recognize Natural and Synthetic Diacylated Sulfoglycolipids from Mycobacterium tuberculosis

Charlotte A. James,1,2 Krystle K.Q. Yu,1 Martine Gilleron,3 Jacques Prandi,3 Vijayendar R. Yedulla,4 Zuzanna Z. Moleda,4 Eleonora Diamanti,5 Momin Khan,5 Varinder K. Aggarwal,5 Josephine F. Reijneveld,6 Peter Reinink,6 Stefanie Lenz,6 Ryan O. Emerson,7 Thomas J. Scriba,8 Michael N.T. Souter,9,10 Dale I. Godfrey,9,10 Daniel G. Pellicci,9,10 D. Branch Moody,11 Adriaan J. Minnaard,4 Chetan Seshadri,1 and Ildiko Van Rhijn6,11 1Department of Medicine, University of Washington Medical Center, 750 Republican Street, Suite E663, Seattle, WA 98115, USA 2Department of Pathology, Molecular Medicine and Mechanisms of Disease Program, University of Washington, Seattle, WA 98195, USA 3Institut de Pharmacologie et Biologie Structurale, IPBS, Universite ́ de Toulouse, CNRS, UPS, Toulouse, France 4Stratingh Institute for Chemistry, University of Groningen, 9747AG Groningen, the Netherlands 5School of Chemistry, University of Bristol, Bristol BS8 1TS, UK 6Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, 3584CL Utrecht, the Netherlands 7Adaptive Biotechnologies, Seattle, WA 98102, USA 8South African Tuberculosis Vaccine Initiative and Institute of Infectious Disease and Molecular Medicine, Division of Immunology, Department of Pathology, University of Cape Town, Cape Town 7935, South Africa 9Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia 10Australian Research Council Centre of Excellence for Advanced Molecular Imaging, University of Melbourne, Melbourne, VIC 3010, Australia 11Department of Rheumatology, Allergy & Immunology, Brigham and Women’s Hospital, 60 Fenwood Road, Room 6006V, Boston, MA 02115, USA