Clonal kinetics and single-cell transcriptional profiling of CAR-T cells in patients undergoing CD19 CAR-T immunotherapy
Sheih et al.
Nature Communications
January 2020
Authors and Affiliates
Sheih A1, Voillet V2, Hanafi LA1, DeBerg HA3, Yajima M4, Hawkins R1, Gersuk V3, Riddell SR1,5,6, Maloney DG1,5,6, Wohlfahrt ME1, Pande D1, Enstrom MR1, Kiem HP1,5,7, Adair JE1,5,6, Gottardo R2,5,6, Linsley PS3, Turtle CJ8,9,10;
1
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, 98109, USA.
2
Vaccine and Infectious Disease Division and Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, 98109, USA.
3
Benaroya Research Institute at Virginia Mason, Seattle, Washington, 98101, USA.
4
Department of Mathematics and Statistics, Boston University, Boston, Massachusetts, 02215, USA.
5
Department of Medicine, University of Washington, Seattle, Washington, USA.
6
Integrated Immunotherapy Research Center, Fred Hutchinson Cancer Research Center, Seattle, Washington, 98109, USA.
7
Department of Pathology, University of Washington, Seattle, Washington, USA.
8
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, 98109, USA. cturtle@fredhutch.org.
9
Department of Medicine, University of Washington, Seattle, Washington, USA. cturtle@fredhutch.org.
10
Integrated Immunotherapy Research Center, Fred Hutchinson Cancer Research Center, Seattle, Washington, 98109, USA. cturtle@fredhutch.org