Clonal replacement of tumor-specific T cells following PD-1 blockade

Yost KE1, Satpathy AT2,3,4, Wells DK5, Qi Y1, Wang C6, Kageyama R5, McNamara KL7,8,9, Granja JM1,8,10, Sarin KY11, Brown RA12,11, Gupta RK13, Curtis C7,8,9, Bucktrout SL5, Davis MM5,14,15,16, Chang ALS17, Chang HY18,19,20,21,22; 1 Center for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, CA, USA. 2 Center for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, CA, USA. satpathy@stanford.edu. 3 Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. satpathy@stanford.edu. 4 Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA. satpathy@stanford.edu. 5 Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA. 6 iRepertoire Inc, Huntsville, AL, USA. 7 Department of Medicine, Division of Oncology, Stanford University School of Medicine, Stanford, CA, USA. 8 Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA. 9 Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA. 10 Program in Biophysics, Stanford University School of Medicine, Stanford, CA, USA. 11 Department of Dermatology, Stanford University School of Medicine, Redwood City, CA, USA. 12 Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. 13 Stanford Biobank, Stanford University School of Medicine, Palo Alto, CA, USA. 14 Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA. 15 Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA. 16 Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA, USA. 17 Department of Dermatology, Stanford University School of Medicine, Redwood City, CA, USA. alschang@stanford.edu. 18 Center for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, CA, USA. howchang@stanford.edu. 19 Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA. howchang@stanford.edu. 20 Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA. howchang@stanford.edu. 21 Department of Dermatology, Stanford University School of Medicine, Redwood City, CA, USA. howchang@stanford.edu. 22 Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA, USA. howchang@stanford.edu.