Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells

Joseph A. Fraietta1,2,3,4, Christopher L. Nobles5, Morgan A. Sammons6,10, Stefan Lundh1,2, Shannon A. Carty2,11, Tyler J. Reich1,2, Alexandria P. Cogdill1,2, Jennifer J. D. Morrissette3, Jamie E. DeNizio7,8, Shantan Reddy5, Young Hwang5, Mercy Gohil1,2,Irina Kulikovskaya1,2, Farzana Nazimuddin1,2, Minnal Gupta1,2, Fang Chen1,2, John K. Everett5, Katherine A. Alexander6, Enrique Lin-Shiao6, Marvin H. Gee9, Xiaojun Liu1,2, Regina M. Young1,2, David Ambrose1,2, Yan Wang1,2, Jun Xu1,2, Martha S. Jordan2,3, Katherine T. Marcucci1,2, Bruce L. Levine1,2,3, K. Christopher Garcia9, Yangbing Zhao1,2, Michael Kalos1,2,3, David L. Porter1,2,7, Rahul M. Kohli5,7,8, Simon F. Lacey1,2,3, Shelley L. Berger6, Frederic D. Bushman5, Carl H. June1,2,3,4 &J. Joseph Melenhorst1,2,3,4 1Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. 2Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. 3Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. 4Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, PA, USA. 5Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. 6Department of Cell and Developmental Biology, Epigenetics Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. 7Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. 8Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. 9Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA. 10Present address: Department of Biology, University at Albany, State University of New York, Albany, NY, USA. 11Present address: Department of Internal Medicine and Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA