Effector TH17 Cells Give Rise to Long-Lived TRM Cells that Are Essential for an Immediate Response against Bacterial Infection

Amezcua Vesely MC1, Pallis P2, Bielecki P2, Low JS2, Zhao J3, Harman CCD1, Kroehling L2, Jackson R2, Bailis W2, Licona-Limón P4, Xu H2, Iijima N2, Pillai PS5, Kaplan DH6, Weaver CT7, Kluger Y8, Kowalczyk MS9, Iwasaki A1, Pereira JP2, Esplugues E10, Gagliani N11, Flavell RA12.; 1 Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT, USA. 2 Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA. 3 Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA; Department of Pathology, Yale School of Medicine, New Haven, CT 06510, USA; Program of Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA. 4 Departamento de Biología Celular y del Desarrollo, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad de México, México. 5 Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA; Koch Institute for Integrative Cancer Research and Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. 6 Department of Dermatology and Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA. 7 Departments of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. 8 Department of Pathology, Yale School of Medicine, New Haven, CT 06510, USA; Program of Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA; Applied Mathematics Program, Yale University, New Haven, CT 06511, USA. 9 Broad Institute of MIT and Harvard, Cambridge, MA, USA. 10 Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA; Laboratory of Molecular and Cellular Immunology, Principe Felipe Research Center (CIPF), 46012 Valencia, Spain. 11 Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA; I. Medical Department and Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf 20246 Hamburg, Germany; Immunology and Allergy Unit, Department of Medicine Solna, Karolinska Institute, 17176 Stockholm, Sweden. Electronic address: n.gagliani@uke.de. 12 Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT, USA. Electronic address: richard.flavell@yale.edu