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Evolution of Neoantigen Landscape During Immune Checkpoint Blockade in Non-Small Cell Lung Cancer

Anagnostou et al.
Cancer Discovery
Papers
January 2017
Authors and Affiliates
Valsamo Anagnostou1,2*, Kellie N. Smith1,2, Patrick M. Forde1,2, Noushin Niknafs3, Rohit Bhattacharya3, James White1, Theresa Zhang4, Vilmos Adleff1, Jillian Phallen1, Neha Wali1, Carolyn Hruban1, Violeta B. Guthrie3, Kristen Rodgers5, Jarushka Naidoo1,2, Hyunseok Kang1, William Sharfman1, Christos Georgiades6, Franco Verde7, Peter Illei1,8, Qing Kay Li8, Edward Gabrielson1,8, Malcolm V. Brock1,5, Cynthia A. Zahnow1, Stephen B. Baylin1, Rob Scharpf1, Julie R. Brahmer1,2, Rachel Karchin3, Drew M. Pardoll1,2 and Victor E. Velculescu1,2,3,8 1The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA, 2The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA 3Institute for Computational Medicine, Johns Hopkins University, Baltimore, Maryland 21204, USA, 4Personal Genome Diagnostics, Baltimore, MD 21224, USA, 5Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA, 6Department of Radiology and Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA, 7Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA, 8Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA