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Fractionated radiation therapy stimulates anti-tumor immunity mediated by both resident and infiltrating polyclonal T-cell populations when combined with PD1 blockade

Dovedi et al.
Clinical Cancer Research
Papers
May 2017
Authors and Affiliates
Simon J. Dovedi1,2, Eleanor J. Cheadle1, Amy L. Popple1, Edmund Poon2, Michelle Morrow2, Ross Stewart2, Erik C. Yusko3, Catherine M. Sanders3, Marissa Vignali3, Ryan O. Emerson3, Harlan S. Robins4, Robert W. Wilkinson2, Jamie Honeychurch1, Timothy M. Illidge1 1Targeted Therapy Group, Targeted Therapy Group, Division of Molecular and Clinical Cancer Sciences, Manchester Cancer Research Centre, Christie Hospital, Manchester Academic Health Sciences Centre, United Kingdom. 2MedImmune Ltd, Granta Park, Cambridge, United Kingdom. 3Adaptive Biotechnologies, Seattle, Washington, United States of America. 4Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.