Fulminant Myocarditis with Combination Immune Checkpoint Blockade

Douglas B. Johnson, M.D.,1 Justin M. Balko, PharmD, Ph.D.,1,2,4 Margaret L. Compton, M.D.,5 Spyridon Chalkias, M.D.,10,11 Joshua Gorham, B.A.,14 Yaomin Xu, Ph.D.,6,8,9 Mellissa Hicks, Ph.D.,1 Igor Puzanov, M.D.,1 Matthew R. Alexander, M.D., Ph.D.,1 Tyler L. Bloomer, M.D.,1 Jason Becker, M.D.,1 David A. Slosky, M.D.,1,3 Elizabeth J. Phillips, M.D.,1 Mark A. Pilkinton, M.D., Ph.D.,1 Laura Craig-Owens, M.D.,5 Nina Kola, M.D.,16 Gregory Plautz, M.D.,16 Daniel S. Reshef, M.D.,16 Jonathan S. Deutsch, M.D.,16 Raquel P. Deering, Ph.D.,17 Benjamin A. Olenchock, M.D., Ph.D.,12 Andrew H. Lichtman, M.D.,13 Dan M. Roden, M.D.,1,7,8 Christine E. Seidman, M.D.,12,14,15 Igor J. Koralnik, M.D.,11 Jonathan G. Seidman, Ph.D.,12,14 Robert D. Hoffman, M.D., Ph.D.,5 Janis M. Taube, M.D.,18,19 Luis A. Diaz, Jr., M.D.,20 Robert A. Anders, M.D.,18 Jeffrey A. Sosman, M.D.,1 and Javid J. Moslehi, M.D.1,2,3 1Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 2Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, TN 3Department of Cardio-Oncology Program, Vanderbilt University Medical Center, Nashville, TN 4Department of Breast Cancer Research Program, Vanderbilt University Medical Center, Nashville, TN 5Department of Pathology Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 6Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 7Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 8Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN 9Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN 10Department of Medicine, Beth Israel Deaconess Medicine Center, Boston, MA 11Division of Neuro-Immunology, Beth Israel Deaconess Medicine Center, Boston, MA 12Department of Medicine, Brigham and Women’s Hospital, Boston, MA 13Department of Pathology, Brigham and Women’s Hospital, Boston, MA 14Department of Genetics, Howard Hughes Medical Institute, Boston, MA 15Harvard Medical School, Howard Hughes Medical Institute, Boston, MA 16Bristol Myers Squibb, New York, NY 17Neon Therapeutics, Cambridge, MA 18Department of Pathology, Johns Hopkins University, Baltimore, MD 19Department of Dermatology, Johns Hopkins University, Baltimore, MD 20Department of Oncology, Johns Hopkins University, Baltimore, MD