Gut and liver T-cells of common clonal origin in primary sclerosing cholangitis-inflammatory bowel disease

Eva Kristine Klemsdal Henriksen1,2,3,4, Kristin Kaasen Jørgensen1,5, Fatemeh Kaveh3,4,6, Kristian Holm1,2,3,4, David Hamm7, Johanna Olweus3,8,9, Espen Melum1,2,3,10, Brian K. Chung1,4,13, Tor J. Eide4,11, Knut E.A. Lundin10,12, Kirsten Muri Boberg1,3,4,10, Tom H. Karlsen1,2,3,4,10,Gideon M. Hirschfield13, Evaggelia Liaskou13,⇑ 1Norwegian PSC Research Center, Department of Transplantation Medicine, Division of Surgery, Inflammatory Medicine and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, Norway; 2Research Institute of Internal Medicine, Division of Surgery, Inflammatory Medicine and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, Norway; 3K.G. Jebsen Inflammation Research Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; 4Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway; 5Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway; 6Department of Medical Genetics, Oslo University Hospital Ullevål, Oslo, Norway; 7Adaptive Biotechnologies Corp., Seattle, WA, USA; 8Department of Cancer Immunology, Institute for Cancer Research,Oslo University Hospital Radiumhospitalet, Oslo, Norway; 9K.G. Jebsen Center for Cancer Immunotherapy, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; 10Section of Gastroenterology, Department of Transplantation Medicine, Division of Surgery, Inflammatory Medicine and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, Norway; 11Department of Pathology, Oslo University Hospital Rikshospitalet, Oslo, Norway; 12Centre for Immune Regulation, Faculty of Medicine, University of Oslo, Oslo, Norway; 13Centre for Liver Research and NIHR Birmingham Biomedical Research Unit, Institute of Biomedical Research, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK