Human retinoic acid–regulated CD161+ regulatory T cells support wound repair in intestinal mucosa

Povoleri GAM1,2, Nova-Lamperti E1,2, Scottà C1,2, Fanelli G1,2, Chen YC3, Becker PD1,2, Boardman D1,2, Costantini B4, Romano M1,2, Pavlidis P1,2, McGregor R1,2, Pantazi E1,2, Chauss D5, Sun HW6, Shih HY7, Cousins DJ8, Cooper N9, Powell N1,2, Kemper C10, Pirooznia M3, Laurence A11, Kordasti S4, Kazemian M12, Lombardi G1,2, Afzali B13,14,15 1 MRC, Centre for Transplantation, King's College London, London, UK. 2 National Institute for Health Research Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust and King's College London, London, UK. 3 Bioinformatics and Computational Biology Core, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA. 4 Comprehensive Cancer Centre, School of Cancer and Pharmaceutical Sciences, King's College London, London, UK. 5 Immunoregulation Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA. 6 Biodata Mining and Discovery Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA. 7 Lymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA. 8 Department of Infection, Immunity and Inflammation, NIHR Leicester Respiratory Biomedical Research Unit, University of Leicester, Leicester, UK. 9 Department of Medicine, Imperial College London, London, UK. 10 Complement and Inflammation Research Section, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA. 11 Institute of Cellular Medicine, Newcastle University, Newcastle, UK. 12 Departments of Biochemistry and Computer Science, Purdue University, West Lafayette, IN, USA. 13 MRC, Centre for Transplantation, King's College London, London, UK. behdad.afzali@nih.gov. 14 Immunoregulation Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA. behdad.afzali@nih.gov. 15 National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA. behdad.afzali@nih.gov.