Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer

Vinod P. Balachandran1,2,3, Marta Łuksza4, Julia N. Zhao1,2,3, Vladimir Makarov5,6, John Alec Moral1,2,3, Romain Remark7, Brian Herbst2, Gokce Askan2,8, Umesh Bhanot8, Yasin Senbabaoglu9, Daniel K. Wells10, Charles Ian Ormsby Cary10, Olivera Grbovic-Huezo2, Marc Attiyeh1,2, Benjamin Medina1, Jennifer Zhang1, Jennifer Loo1, Joseph Saglimbeni2, Mohsen Abu-Akeel9, Roberta Zappasodi9, Nadeem Riaz6,11, Martin Smoragiewicz12, Z. Larkin Kelley13,14, Olca Basturk8, Mithat Gönen15, Arnold J. Levine4, Peter J. Allen1,2, Douglas T. Fearon13,14, Miriam Merad7, Sacha Gnjatic7, Christine A. Iacobuzio-Donahue2,5,8, Jedd D. Wolchok3,9,16,17,18, Ronald P. DeMatteo1,2, Timothy A. Chan3,5,6,11, Benjamin D. Greenbaum19, Taha Merghoub3,9,18 & Steven D. Leach1,2,5,20 1Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA. 2David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, New York, USA. 3Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, New York, USA. 4The Simons Center for Systems Biology, Institute for Advanced Study, Princeton, New Jersey, USA. 5Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA. 6Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, New York, USA. 7Tisch Cancer Institute, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA. 8Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA. 9Swim Across America/Ludwig Collaborative Laboratory, New York, New York, USA. 10Parker Institute for Cancer Immunotherapy, San Francisco, California, USA. 11Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA. 12Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK. 13Cold Spring Harbor Laboratory, New York, New York, USA. 14Department of Microbiology and Immunology, Weill Cornell Medical School, New York, New York, USA. 15Department of Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA. 16Melanoma and Immunotherapeutics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA. 17Weill Cornell Medical College, Cornell University, New York, New York, USA. 18Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA. 19Tisch Cancer Institute, Departments of Medicine, Hematology and Medical Oncology, Oncological Sciences, and Pathology, Icahn School of Medicine at Mount Sinai, New York, New York, USA. 20Dartmouth Norris Cotton Cancer Center, Lebanon, New Hampshire, USA