Immunological Ignorance Is an Enabling Feature of the Oligo-Clonal T Cell Response to Melanoma Neoantigens

Gerald P Linette 1 2 3 4, Michelle Becker-Hapak 5 6 7, Zachary L Skidmore 5 6 7, Miren Lorea Baroja 1 2 3 4, Chong Xu 1 2 3 4, Jasreet Hundal 5 6 7, David H Spencer 5 6 7, Weixuan Fu 1 2 3 4 8, Casey Cummins 1 2 3 4, Maya Robnett 1 2 3 4, Saghar Kaabinejadian 9, William H Hildebrand 9, Vincent Magrini 10 11, Ryan Demeter 5 6 7, Alexander S Krupnick 12, Obi L Griffith 5 6 7, Malachi Griffith 5 6 7, Elaine R Mardis 10 11, Beatriz M Carreno 13 2 3 4; 1Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104. 2The Parker Institute for Cancer Immunotherapy, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104. 3Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104. 4Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104. 5McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63110. 6Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110. 7Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110. 8Bioinformatics Core, Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104. 9Department of Microbiology and Immunology, University of Oklahoma Health Science Center, Oklahoma City, OK 73104. 10Institute for Genomic Medicine, Nationwide Children's Hospital, Ohio State University College of Medicine, Columbus, OH 43205. 11Department of Pediatrics, Ohio State University College of Medicine, Columbus, OH 43205. 12Department of Surgery, University of Virginia, Charlottesville, VA 22908. 13Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104; bcarreno@upenn.edu.