Key Residues at Third CDR3β Position Impact Structure and Antigen Recognition of Human Invariant NK TCRs

Kenji Chamoto*,1, Tingxi Guo*,†,1, Stephen W. Scally‡, Yuki Kagoya*, Mark Ancruzowski*,†, Chung-Hsi Wang*,†, Muhammed A. Rahman*, Kayoko Saso*, Marcus O. Butler*,†,§, Priscilla P. L. Chiu¶,‖, Jean-Philippe Julien†,‡,# and Naoto Hirano*,† *Tumor Immunotherapy Program, Campbell Family Institute for Breast Cancer Research, Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2M9, Canada; †Department of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada; ‡Program in Molecular Structure and Function, The Hospital for Sick Children Research Institute, Toronto, Ontario M5G 0A4, Canada; §Department of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada; ¶Division of Pediatric Surgery, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada; ‖Department of Surgery, University of Toronto, Toronto, Ontario M5S 1A8, Canada; and #Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada