Ligase-4 Deficiency Causes Distinctive Immune Abnormalities in Asymptomatic Individuals

Kerstin Felgentreff1,2 & Sachin N. Baxi1 & Yu Nee Lee1 & Kerry Dobbs1 & Lauren A. Henderson1 & Krisztian Csomos3 & Erdyni N. Tsitsikov4 & Mary Armanios5 & Jolan E. Walter1,3 & Luigi D. Notarangelo1,6 1Division of Immunology, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA. 2 Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany. 3 Pediatric Allergy and Immunology and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. 4 Department of Laboratory Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA. 5 Departments of Oncology, Pathology and McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. 6 Harvard Stem Cell Institute, Harvard University, Boston, MA, USA.