Mismatch-repair deficiency predicts response of solid tumors to PD-1 blockade

Dung T. Le,1,2,3 Jennifer N. Durham,1,2,3 Kellie N. Smith,1,3 Hao Wang,3 Bjarne R. Bartlett,2,4 Laveet K. Aulakh,2,4 Steve Lu,2,4 Holly Kemberling,3 Cara Wilt,3 Brandon S. Luber,3 Fay Wong,2,4 Nilofer S. Azad,1,3 Agnieszka A. Rucki,1,3 Dan Laheru,3 Ross Donehower,3 Atif Zaheer,5 George A. Fisher,6 Todd S. Crocenzi,7 James J. Lee,8 Tim F. Greten,9 Austin G. Duffy,9 Kristen K. Ciombor,10 Aleksandra D. Eyring,11 Bao H. Lam,11 Andrew Joe,11 S. Peter Kang,11 Matthias Holdhoff,3 Ludmila Danilova,1,3 Leslie Cope,1,3 Christian Meyer,3 Shibin Zhou,1,3,4 Richard M. Goldberg,12 Deborah K. Armstrong,3 Katherine M. Bever,3 Amanda N. Fader,13 Janis Taube,1,3 Franck Housseau,1,3 David Spetzler,14 Nianqing Xiao,14 Drew M. Pardoll,1,3 Nickolas Papadopoulos,3,4 Kenneth W. Kinzler,3,4 James R. Eshleman,15 Bert Vogelstein,1,3,4 Robert A. Anders,1,3,15 Luis A. Diaz Jr.1,2,3 1Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, MD 21287, USA. 2Swim Across America Laboratory at Johns Hopkins, Baltimore, MD 21287, USA. 3Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA. 4Ludwig Center and Howard Hughes Medical Institute at Johns Hopkins, Baltimore, MD 21287, USA. 5Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. 6Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. 7Providence Cancer Center at Providence Health & Services, Portland, OR 97213, USA. 8Department of Medicine, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15232, USA. 9Gastrointestinal Malignancies Section, Thoracic-GI Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. 10Division of Medical Oncology, Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA. 11Merck & Co. Inc., Kenilworth, NJ 07033, USA. 12West Virginia University Cancer Institute, Morgantown, WV 26506, USA. 13Department of Gynecology and Obstetrics, Johns Hopkins Medicine, Baltimore, MD 21287, USA. 14Caris Life Sciences, Phoenix, AZ 85040, USA. 15Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.