Molecular constraints on CDR3 for thymic selection of MHC-restricted TCRs from a random pre-selection repertoire.

Lu J1, Van Laethem F2, Bhattacharya A2, Craveiro M2, Saba I2, Chu J1, Love NC2, Tikhonova A2, Radaev S1, Sun X3, Ko A3, Arnon T4,5, Shifrut E4, Friedman N4, Weng NP3, Singer A6, Sun PD7 1 Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, Rockville, MD, 20852, USA. 2 Experimental Immunology Branch, National Cancer Institute, Bethesda, MD, 20892, USA. 3 Lymphocyte Differentiation Section, Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institute of Health, Baltimore, MD, 21224, USA. 4 Department of Immunology, Weizmann Institute of Science, 76100, Rehovot, Israel. 5 Department of Physics and Astronomy, Alfred University, 1 Saxon Drive, Alfred, NY, 14802, USA. 6 Experimental Immunology Branch, National Cancer Institute, Bethesda, MD, 20892, USA. singera@nih.gov. 7 Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, Rockville, MD, 20852, USA. psun@nih.gov.