Novel E2 Glycoprotein Tetramer Detects Hepatitis C Virus−Specific Memory B Cells

Maude Boisvert,*,1 Wanrui Zhang,†,1 Elizabeth J. Elrod,† Nicole F. Bernard,‡,x Jean-Pierre Villeneuve,*,{ Julie Bruneau,*,‖ Joseph Marcotrigiano,# Naglaa H. Shoukry,*,{ and Arash Grakoui†,** *Centre de Recherche du Centre Hospitalier de l’Universite ́ de Montre ́al, Montreal, Quebec H2X 0A9, Canada; †Yerkes National Primate Research Center, Emory Vaccine Center, Atlanta, GA 30329; ‡Research Institute of the McGill University Health Centre, Montreal, Quebec H4A 3J1, Canada; xDivision of Experimental Medicine, McGill University, Mon- treal, Quebec H3A 1A3, Canada; {De ́partement de Me ́decine,‖ Faculte ́ de Me ́decine, Uni- versite ́ de Montre ́al, Montreal, Quebec H3T 1J4, Canada; De ́partement de Me ́decine Familiale et de Me ́decine D’Urgence, Faculte ́ de Me ́decine, Universite ́ de Montre ́al, Mon- treal, Quebec H3T 1J4, Canada; #Center for Advanced Biotechnology and Medicine, De- partment of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854; and **Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30329 Maude Boisvert, Wanrui Zhang, Elizabeth J. Elrod, Nicole F. Bernard, Jean-Pierre Villeneuve, Julie Bruneau, Joseph Marcotrigiano, Naglaa H. Shoukry and Arash Grakoui