Subclonal STAT3 mutations solidify clonal dominance

Cassandra M. Kerr,1 Michael J. Clemente,1 Peter W. Chomczynski,1 Bartlomiej Przychodzen,1 Yasunobu Nagata,1 Vera Adema,1 Valeria Visconte,1 Alan E. Lichtin,2 Satu Mustjoki,3,4 Tomas Radivoyevitch,5 Mikkael A. Sekeres,2 and Jaroslaw P. Maciejewski1,2 1Department of Translational Hematology and Oncology Research and 2Leukemia Program, Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH; 3Hematology Research Unit Helsinki, University of Helsinki, Helsinki, Finland; 4Department of Hematology, Helsinki University Hospital Comprehensive Cancer Centre, Helsinki, Finland; and 5Quantitative Health Sciences Department, Cleveland Clinic, Cleveland, OH