T cells in patients with narcolepsy target self-antigens of hypocretin neurons

Latorre D1,2, Kallweit U3,4, Armentani E1, Foglierini M1,5, Mele F1, Cassotta A1,2, Jovic S1, Jarrossay D1, Mathis J3, Zellini F6, Becher B7, Lanzavecchia A1, Khatami R8, Manconi M3,6, Tafti M9, Bassetti CL10, Sallusto F11,12 1Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera Italiana, Bellinzona, Switzerland. 2Institute of Microbiology, ETH Zurich, Zurich, Switzerland. 3Department of Neurology, University Hospital, Bern, Switzerland. 4Institute of Immunology, University of Witten/Herdecke, Witten, Germany. 5Swiss Institute of Bioinformatics, Lausanne, Switzerland. 6Sleep and Epilepsy Center, Neurocenter of Southern Switzerland, Lugano, Switzerland. 7Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland. 8Center for Sleep Research and Sleep Medicine, Clinic Barmelweid, Barmelweid, Switzerland. 9Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland. 10Department of Neurology, University Hospital, Bern, Switzerland. 11Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera italiana, Bellinzona, Switzerland. 12Institute of Microbiology, ETH Zurich, Zurich, Switzerland.