Teriflunomide treatment for multiple sclerosis modulates T cell mitochondrial respiration with affinity-dependent effects

Klotz L1, Eschborn M2, Lindner M2, Liebmann M2, Herold M2, Janoschka C2, Torres Garrido B2, Schulte-Mecklenbeck A2, Gross CC2, Breuer J2, Hundehege P2, Posevitz V2, Pignolet B3, Nebel G4, Glander S5, Freise N6, Austermann J6, Wirth T2, Campbell GR7, Schneider-Hohendorf T2, Eveslage M8, Brassat D3, Schwab N2, Loser K9, Roth J6, Busch KB4, Stoll M5,10, Mahad DJ7, Meuth SG2, Turner T11, Bar-Or A12, Wiendl H2,13; 1 University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany. luisa.klotz@ukmuenster.de. 2 University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany. 3 CRC-SEP, Neurosciences Department, Toulouse University Hospital and INSERM U1043 - CNRS UMR 5282, Centre de Physiopathologie Toulouse-Purpan, Université Toulouse III, 31300 Toulouse, France. 4 University of Münster, Institute of Molecular Cell Biology, 48149 Münster, Germany. 5 University of Münster, Department of Genetic Epidemiology, 48149 Münster, Germany. 6 University of Münster, Department of Immunology, 48149 Münster, Germany. 7 University of Edinburgh, Centre for Clinical Brain Sciences, EH8 9YL Edinburgh, UK. 8 University of Münster, Institute of Biostatistics and Clinical Research, 48149 Münster, Germany. 9 University Hospital Münster, Department of Dermatology, 48149 Münster, Germany. 10 Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, 6229 ER Maastricht, Netherlands. 11 Sanofi Genzyme, Cambridge, MA 02142, USA. 12 Center for Neuroinflammation and Experimental Therapeutics and Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. 13 Brain and Mind Centre, Medical Faculty, University of Sydney, Sydney, Camperdown, NSW 2050, Australia.