Tumor and Microenvironment Evolution during Immunotherapy with Nivolumab

Nadeem Riaz,1,2,3 Jonathan J. Havel,1 Vladimir Makarov,1,3 Alexis Desrichard,1 Walter J. Urba,4 Jennifer S. Sims,1,3 F. Stephen Hodi,5 Salvador Martin-Algarra,6 Rajarsi Mandal,7 William H. Sharfman,8 Shailender Bhatia,9 Wen-Jen Hwu,10 Thomas F. Gajewski,11 Craig L. Slingluff, Jr.,12 Diego Chowell,1,3 Sviatoslav M. Kendall,1,3 Han Chang,13 Rachna Shah,1 Fengshen Kuo,3 Luc G.T. Morris,3,7 John-William Sidhom,14 Jonathan P. Schneck,14 Christine E. Horak,13 Nils Weinhold,2 and Timothy A. Chan1,2,3 1Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA 2Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA 3Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA 4Earle A. Chiles Research Institute, Providence Cancer Center, Portland, OR 97213, USA 5Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA 6Medical Oncology, Clinica Universidad de Navarra, Instituto de Investigacion Sanitaria de Navarra, 31008 Pamplona, Spain 7Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA 8Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA 9Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA 98105, USA 10Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA 11Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, IL 60637, USA 12Department of Surgery and University of Virginia Cancer Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA 13Bristol-Myers Squibb, Princeton, NJ 08648, USA 14Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA