Vaccination establishes clonal relatives of germinal center T cells in the blood of humans

Antje Heit,1 Frank Schmitz,3 Sarah Gerdts,1 Britta Flach,1 Miranda S. Moore,1 Jonathan A. Perkins,4,8 Harlan S. Robins,2,9 Alan Aderem,3 Paul Spearman,10 Georgia D. Tomaras,11 Stephen C. De Rosa,1,5 and M. Juliana McElrath1,5,6,7 1Vaccine and Infectious Disease Division and 2Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 3Center for Infectious Disease Research, Seattle, WA, 4Department of Otolaryngology, 5Department of Laboratory Medicine, 6Department of Medicine, and 7Department of Global Health, University of Washington, Seattle, WA, 8Seattle Children's Hospital Research Institute, Seattle, WA, 9Adaptive Biotechnologies Corporation, Seattle, WA, 10Pediatric Infectious Diseases, Cincinnati Children's Hospital, Cincinnati, OH, 11Duke Human Vaccine Institute, Duke University, Durham, NC